INFECT – Vers de nouvelles stratégies thérapeutiques pour améliorer l’issue des infections nécrosantes des tissus mous


Fiche  technique du Projet

• Programme de financement: 7e PCRD – programme cooperation – Santé - 2012
• Coordinateur: Karolinska Institutet (SE), Dr. Anna Norrby-Teglund
• Partenaires :
o Region Hovedstaden - RH (DK)
o Stockholm Laens Landsting - SSL (SE)
o Blekinge Lans Landsting (BLS) – (SE)
o Vastra Gotalands Lans landsting - SU (SE)
o Universitet I Bergen (NO)
o University of Cincinnati (USA)
o Helmholtz Centre for Infection Research (DE)
o Wageningen Universiteit (NL)
o Université Claude Bernard Lyon 1 (FR)
o Lifeglimmer gmbh (DE)
o Anagnostics Bioanalysis Gmbh (AT)
o Marsden Doreen (UK)
o Tel Aviv University (IL)

• Budget Total: € 15.678.948
• Subvention : € 11.913.591
• Durée : 2013-2018
• Site web : http://www.fp7infect.eu/

Context / Contexte

Tissue infections is usually caused by bacteria, such as staphylococci or streptococci . Often the infections are mild and heal completely with antibiotic treatment. However, some cases of tissue can be severe and lead to generalized infection. Necrotizing soft tissue infections (NSTIs) are the most extreme and severe end of skin and soft tissue infections. These infections are rapidly spreading and can progress in inches per hour with extensive tissue necrosis as a result. The vast majority of patients require intensive care and extensive surgical interventions to remove necrotic tissue, and despite modern intensive care, the mortality associated with NSTIs is high, often exceeding 30%. Patients affected by NSTIs are highly heterogeneous, ranging from young immunocompetent individuals to individuals with co-morbidities, including among others diabetes mellitus, peripheral vascular disease, chronic renal failure, and recent trauma. The fulminant course of NSTIs (in the order of hours) demands immediate diagnosis and adequate interventions to salvage lives and limbs. Although, it is undisputed that rapid diagnosis and prompt intervention is directly related to survival, the diagnosis is often difficult due to vague initial symptoms that may result in a doctor’s delay, and treatment is complicated due to the great heterogeneity of these infections, including a wide variety of causative microorganisms and varying co-morbidities. Recent reports have underscored the urgent need for improved diagnosis as well as evidence-based schemes for identification and management of these sever tissue infections. The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal NSTIs.

Objectives / objectifs

The overall goal with INFECT is to advance our understanding of the pathophysiological mechanisms, prognosis, and diagnosis of the multifactorial highly lethal necrotizing soft tissue infections (NSTIs).
The research in INFECT is focused on six distinct, yet highly integrated objectives:
- Unravel specific mechanisms underlying diseases signatures though a bottom-up systems approach applied to clinically relevant experimental
- Apply a top-down systems biology approach to NSTI patient samples to pin-point key host and pathogen factors involved in the onset and development of infection
- Identify and quantify disease signatures and underlying networks that contribute to disease outcome
- Identify novel therapeutic strategies for NSTI
- Exploit identified disease traits for the innovation of optimized diagnostic tools
- Translate the advanced knowledge generated in INFECT into evidence-based guidelines for classification and management.

Impact / results - Impact / résultats

There is convincing evidence that the clinical and economic effects of these severe infections are substantial and growing, emphasizing the urgent need for advances in this field. In INFECT we propose to achieve such advances by employing, for the first time, an integrated systems biology approach to study this multifactorial disease and translate results into novel diagnostics and evidence-based guidelines.
The expected impact of INFECT is broad and involves several different areas, outlined below:
-Novel insights into the pathophysiology of NSTIs
-Patient benefit: superior diagnosis
-Patient benefit: guidelines and novel therapeutic strategies
-Design/optimization of future clinical trials
-Reduction on health care costs
-Establishment of the value of systems medicine in solving complex human diseases
-Fostering the competitiveness of SMEs and European innovation
-Training of early stage and experienced researchers

 

Rôle de LIP

LIP a accompagné le partenaire du projet dans toute la phase de montage et la phase de négociation du projet. LIP assure le suivi administratif et financier du projet pour l’Université Lyon 1, en lien avec les services administratifs et financiers de l’Université.