BONENET –Formation de  jeunes chercheurs internationaux sur les mécanismes moléculaires liés aux métastases osseuses, visant à identifier de nouvelles thérapies ciblées/ Training of international young researchers on the early molecular mechanisms of bone metastases in order to develop molecularly-targeted therapies.


Fiche  technique du Projet

• Programme: 7PC  – Personnes – “ Formation initiale des chercheurs ”
• Coordinateur: Université Claude Bernard Lyon 1, Prof.  Philippe CLEZARDIN
• Partenaires : • Université Claude Bernard Lyon 1 (FR)
• University of Eastern Finland (FI)
• Leiden University Medical Centre (NL)
• University of Liège (BE)
• University of Nantes (FR)
• Universitätsklinikum Hamburg-Eppendorf (GE)
• University of Sheffield (UK)
• ServiceXS (NL)
• PerkinElmer (partenaire associé)

• Budget total: € 3.263.864
• Subvention : € 3.263.864
• Durée : 2011-2015
• Site web : www.bonenet.eu

Context / Contexte

More than 400,000 European men and women are diagnosed every year with prostate and breast cancer, respectively. These cancers are prone to metastasize to bone. Combating bone metastasis, especially the early dissemination of cancer cells in bone, requires basic research knowledge, skills in different technologies and longstanding clinical experience in order to make clinically significant progress.

Objectives / objectifs

The BONE-NET project aim at investigating the early molecular mechanisms of metastases associated with breast and prostate cancers and primary bone cancers (e.g., osteosarcomas), including the identification of new gens and their regulators (microRNAs) that draw cancer cells to colonize bone and let these cells adapt and thrive in the bone marrow. This network will then seek to identify and develop molecularly-targeted therapies.
Based on this research program, BONE-NET’s objective will be to train 10 early-stage (ESR) and 4 experienced (ER) researchers in technical skills such as genomics, proteomics, advance microscopical methods, animal experimentation, noninvasive in vivo imaging methodologies and drug development. The training programme will also expose the ESR/ER to the industry which will offer courses and a set of complementary skills (ethics, intellectual property rights, entrepreneurship), thereby enabling to gain industrial work experience. The network additional objective will be to foster collaborations between participating laboratories, in which ESR/ER will take part through individual training-through-research projects.

Impact/ results – Impact/résultats

The BONE-NET training programme will allow ESR/ERs to become experts in many disciplines and techniques thanks to the participation workshops, courses and secondments. Moreover, it will expose the young researchers to the private sector which will offer courses and a set of complementary skills including ethics, entrepreneurship and intellectual property rights, thereby enabling the ESR/ERs to gain industrial work experience. Finally, ESR/ERs will attend the network internal meetings where the research plan will be discussed and where the project management (administrative and financial aspects) will also be reviewed by the partners. Overall, at the end of the project, ESR/ERs will have acquired enough skills to be able to manage their own research programmes.

Role of LIP

LIP is involved in the project from the setting up phase. LIP is a Third Party of the coordinator (Université Claude Bernard Lyon 1). Lip’s role is to support the coordinator in the financial administrative management of the network. LIP is also in charge of the update of the project web site.